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Antidepressant medication protects against compounds linked to dementia

first_imgShare Share on Facebook In addition to treating depression, a commonly used antidepressant medication also protects against compounds that can cause memory loss and dementia, a Loyola University Medical Center study has found.The study found that blood levels of two neurotoxic compounds dropped significantly in depressed patients after they were treated with the antidepressant escitalopram (Lexapro®).The study, published in the Journal of Psychiatric Research, provides new insights into how the immune system responds to depression. LinkedIn Share on Twittercenter_img Email Pinterest Stress and depression interact in a vicious cycle. Stress can lead to depression in susceptible individuals. In turn, depression, if not treated, causes stress. This stimulates the body’s immune system to fight stress and depression, as it would a disease or infection. Revving up the immune system, which includes the inflammatory response, initially protects against stress. But over time, chronic inflammation can cause a range of health problems.In this vicious cycle, depression can trigger an inflammatory response, which in turn can exacerbate depression, said Angelos Halaris, MD, PhD, lead author of the study and a professor in the Department of Psychiatry and Behavioral Neurosciences of Loyola University Chicago Stritch School of Medicine.“It behooves us to diagnose depression early, treat it vigorously to achieve remission and work to prevent its relapse,” Dr. Halaris said.The study compared 30 severely depressed patients with 27 healthy subjects. The patients were treated with escitalopram and followed for 12 weeks. Some patients dropped out of the study due to side effects of escitalopram or other reasons. Of the 20 patients who completed the entire study, 80 percent reported complete or partial relief from their depression.To examine the inflammatory response, researchers measured blood levels of nine substances secreted by the immune system. At the beginning of the study, average levels of all nine of these substances were higher in the depressed patients than in the healthy subjects. The differences were statistically significant with four of these substances (hsCRP, TNFα, IL6 and MCP1).The inflammatory response can lead to the production of neurotoxic compounds that can kill brain cells, leading to memory loss and dementia if the depression goes untreated or fails to respond adequately to treatment. The study found that among patients treated with escitalopram, levels of two neurotoxic compounds dropped significantly. Levels of 3-hydroxykynurenine fell by more than two-thirds between week 8 and week 12. Levels of quinolinic acid dropped 50 percent during the first eight weeks and were lower at the end of the study than at the beginning.Escitalopram belongs to a class of antidepressants called selective serotonin reuptake inhibitors (SSRIs). It’s possible that other SSRIs, such as Prozac®, Paxil® and Zoloft®, also could protect against neurotoxins, but this would have to be confirmed with other studies, Dr. Halaris said.The study is limited by the small number of subjects. But it should stimulate interest in replicating the findings with larger groups over a longer period of time, researchers wrote.The study is titled “Does escitalopram reduce neurotoxity in major depression?”last_img read more

Bill Nye Experiment Night At Bradbury Friday Nov. 15

first_imgBradbury Science Museum at 1350 Central Ave. Courtesy/BSMBSMA News:It’s Bill Nye Experiment Night Friday, Nov. 15 at the Bradbury Science Museum, 1350 Central Ave.Hosted by the Bradbury Science Museum Association Teen Advisory Board, Bill Nye Experiment Night provides teens the opportunity to perform experiments featured in Bill Nye videos.The event includes free food.The BSMA Teen Advisory Board was created in 2018 by Los Alamos High School senior Eleanor Henderson for her Girl Scout Gold Award project. She serves as president of the Board along with Vice President Emily Holmes, Secretary/Treasurer Neha Sadasivan, BSMA Liaison Ogden Berry, Public Relations/Advertising Officer Noah Lyons, Sonya Svyatskaya, Natalie Aulwes, Steven Bullock, Samuel Cirigliano, Filippo Delzanno, Victor Popa-Simil and Malea Joyce.The Teen Advisory Board hopes to increase teen interest in the Bradbury as well as in STEM, and they are looking forward to making a positive impact in the Los Alamos community. They are accepting new applicants for the board (applicants must be high school-aged), through Nov. 30. To access the application, visit https://sites.google.com/view/bsmateens/home.For more information about the board, including questions about applications, email [email protected] or check out their Instagram page @bradburyteens.last_img read more

Equal civil marriage – death of spouse

first_imgA particular problem to be considered in drafting equal civil marriage legislation is the fact that whatever arrangements are made for the UK, same-sex marriages performed here will not be recognised in most countries of the world. In today’s highly mobile society, that potentially creates serious difficulties for same-sex couples. Essentially these are the same as those that arise under the Civil Partnership Act 2004 (the 2004 act), and the solutions adopted there should be extended to the new regime for same-sex marriage. Unfortunately, however, problems have arisen in practice which were not anticipated when civil partnership was introduced, and changes have been made or proposed to the civil partnership legislation which ignore the international element. The simplest case is that of divorce. When same-sex marriage was introduced in Canada, many American couples got married there only to discover later that they could not get divorced where they lived in the US because their marriage was not recognised there, nor could they get divorced in Canada without fulfilling Canadian residence requirements. This problem was avoided in the UK under section 221 of the 2004 act, which provides potentially for the English courts to have jurisdiction to dissolve any civil partnership entered into in England or in a British consulate under English law. This article focuses on the more troublesome case of the death or disappearance overseas of a civil partner or same-sex spouse. Unlike the position in the UK, in many countries the registry of births and deaths is not open to the public. In Malaysia, for example, only immediate family members may obtain death certificates directly from the registry. Other persons must apply through a solicitor, who must furnish reasons satisfactory to the authorities as to why the death certificate is required. Civil partnerships and same-sex marriages are not recognised under Malaysian law, so a British civil partner or same-sex spouse would not be able to obtain a death certificate for his/her partner/spouse directly from the Malaysian Registry. As homosexuality is a criminal offence under Malaysian law, it would be inadvisable for the surviving civil partner or spouse to state his or her true relationship with the deceased when applying through a solicitor to obtain a death certificate. Obviously this creates a difficulty in supplying a reason satisfactory to the authorities for the issue of the death certificate. Where it is not possible to obtain a foreign death certificate at all, the surviving partner’s only recourse may be to apply to the English courts for a presumption of death order under the 2004 act. This is considered further below. Where a foreign death certificate has been obtained, a practical difficulty occurs should this document be mislaid or should further death certificates be required. Where the deceased was a British national, this problem can be avoided by registering the death with the Foreign and Commonwealth Office or with the British consular authorities overseas, but this can only be done where the foreign death certificate can be produced. See the commonwealth office’s site. The advantage of this procedure is that a British-style death certificate will be issued and a permanent record kept at the General Register Office in the UK, where further death certificates can be obtained. Where the deceased was not a British national, there is currently no way to obtain further death certificates except by applying again to the foreign authorities with all the difficulties that may involve. There is potentially a very simple solution to this problem, which would be for the UK General Register Office to accept the deposit of foreign death certificates of civil partners or spouses of British citizens. Currently, the General Register Office in the UK does accept the deposit of foreign same-sex marriage certificates or foreign civil partnership certificates where one of the spouses or partners is a British citizen (2004 act, section 241). This would therefore be only a slight extension of existing practice, but it would require legislation. Particular difficulties occur where a couple lives overseas and one goes missing. It is worth drawing attention particularly to this case because it appears to have been overlooked in the Presumption of Death Act (Northern Ireland) 2009 and in the Presumption of Death and Provisions Relating to Missing Persons Bill, which was introduced in the House of Lords on 14 May 2012 by Baroness Susan Kramer. As mentioned above, the problem is that UK civil partnerships (and same-sex marriages, should these be introduced) are recognised by very few foreign countries. As an example, suppose A and B enter into a civil partnership in England (or in a British consulate overseas under English law), but live in a country (e.g. Singapore), which does not recognise civil partnerships. A then goes missing. In these circumstances, since they do not recognise the relationship between A and B, the Singapore courts will not grant B an order stating that A is presumed to have died, nor will they grant a decree of dissolution of the civil partnership. This problem was anticipated when the 2004 act was drafted. Section 222(c) provides that the English courts may grant a presumption of death order, which has the effect of dissolving the civil partnership, where the two people concerned registered as civil partners in England, if it is in the interests of justice for the courts to assume jurisdiction. By virtue of section 210(5), the same applies where the couple registered their civil partnership in a British consulate overseas under English law. Unfortunately, the Presumption of Death and Provisions Relating to Missing Persons Bill 2012 follows the Northern Ireland legislation by proposing to repeal section 222 of the 2004 act. If enacted, this would place someone like B in a very difficult position, should A go missing. The Singapore courts will not grant a presumption of death order in respect of A. The English courts would no longer be able to do so, unless B could show (as required by section 1 of the bill) that he or she was domiciled in England or that his or her civil partner was. Domicile is a very nebulous concept in law and it can be difficult to establish where a person is domiciled. There are also cases of foreign couples from countries which do not recognise civil partnerships, who have taken advantage of the 2004 act to enter into civil partnerships in England, even though they do not live in England and are not domiciled here. What this means in practice for B is that it would be difficult for him or her to enter into another civil partnership or get married again. It would not be possible in the UK, as the civil partnership with A is still in existence. If B is a British citizen, it would be extremely difficult for him or her to do so in any foreign country, as most countries insist on the production of a certificate of no impediment to marriage from the home country before allowing a foreigner to get married or enter into a civil partnership. The British authorities would not be able to issue B with a certificate of no impediment to marriage, given the continued existence of the civil partnership with A. In these circumstances, the only solution for B would appear to be to wait five years and then apply to the English courts for a ‘divorce’ from A (i.e. dissolution of the civil partnership) on the grounds of separation without consent. Needless to say, this is not a satisfactory way of dealing with the problem. The issue of presumption of death orders for same-sex married couples living overseas should obviously be addressed specifically in the equal civil marriage legislation. Given the difficulties in obtaining a death certificate where a same-sex spouse dies overseas, it is particularly important to enable the surviving spouse to obtain a presumption of death order from the English courts. Barry Crown , an English solicitor, is associate professor in the Faculty of Law of the National University of Singaporelast_img read more

Poznań Metropolitan Railway to launch this year

first_imgPOLAND: The creation of a network of regular local passenger services centred on Poznań is to begin this year, after the local authorities reached a funding agreement in December. Poznań Metropolitan Railway services are to be operated by voivodship-owned company Koleje Wielkopolskie.The initial phase is expected to launch in the first half of the year, with trains running up to every 30 min on four routes from Poznań to Wągrowiec, Jarocin, Grodzisk Wielkopolski and Nowy Tomyśl. Services to Rogoźno would be launched in 2019-20, with Września and Kościan added to the network in 2020 and Wronki and Gniezno from 2021. Wielkopolskie voivodship is to provide funding to cover 40% of the operating costs, with the remainder to be met by the local authorities served by the routes.last_img read more

Free agent Hopgood determined to make World Cup squad

first_img KEYWORDS “We always seem to be singled out. It’s not as if we’re breaking any rules and it’s frustrating,” Hayden Hopgood, one of the few non-Japanese passport holders in the squad, said this week at the Brave Blossoms training camp in Miyazaki.And for Hopgood in particular, the term mercenary is as far removed from reality as you can get.Now in his seventh year in Japan, the 34-year-old flanker born in Christchurch, New Zealand, has been without a pay packet since March as he tries to make the squad for this year’s Rugby World Cup.Having played for Toyota Verblitz for five years, Hopgood moved north to play for Kamaishi Seawaves in 2014 with the aim of spending a few seasons in a town rich in rugby history but battling to rebuild following its destruction in the March 2011 earthquake and tsunami.But things didn’t go according to plan.“They told me that because the World Cup team was away for so long they wouldn’t renew my contract,” Hopgood told Kyodo News.“I was a bit gutted. I enjoyed my time up there. It’s a beautiful wee town and they are really good people and obviously the community is rebuilding since 2011. They are really pushing rugby and are going to be hosting games in (Rugby World Cup) 2019 so it’s a fantastic environment.“But (second division) Top East starts in September so it would mean missing five or six games and they seemed certain I would make the World Cup squad.”With the Seawaves leaving it late to make their decision and most of the other top sides in Japan having already lined up their “foreign” players for next season, Hopgood is resigned to missing the whole of the 2015-16 season in Japan.“If nothing else does come up I’ll just go home and get back to work,” said the former Hurricanes and Chiefs flanker, who is a qualified exterior plasterer.For now though, Hopgood is doing all he can to be on the list of 31 players that Japan coach Eddie Jones will name on Aug. 31 for the world’s third-biggest sporting event.“It’s obviously tough on my family and my wife especially as we had our first child two weeks ago, but it’s an unbelievable opportunity so I might as well have a crack and good go at it,” he said.Hopgood said it had been “awesome to play for Japan, the highlight of my playing career,” and that making the World Cup squad would be “a dream come true.”“But it’s going to be tough,” he said. “We’ve got a lot of good flankers so I will just have to put my best foot forward and put my hand up for selection.”On Sunday, Japan leaves for North America, where it will play four Pacific Nations Cup games. It then plays a World XV on Aug. 15 and two tests against Uruguay before Jones must make his final cut.“I could be around for five weeks or it could be three months,” said Hopgood, who has played seven tests for Japan to date. “But whatever happens, it’s been an amazing experience.” Brave Blossoms, 2015 Rugby World Cup, Hayden Hopgood MIYAZAKI – Japan has for many years been criticized for the number of non-Japan-born players playing for its national rugby team.“Rugby mercenaries” is a term that has been used both within and from outside Japan, even though the Brave Blossoms are no different from England, France and Australia in making use of the three-year eligibility rule.center_img GET THE BEST OF THE JAPAN TIMES IN FIVE EASY PIECES WITH TAKE 5last_img read more

Miura loses title bid by decision

first_img GET THE BEST OF THE JAPAN TIMES “He completely shut me down,” the left-handed Miura said. “He stayed out of range of my left, so it was hard to hit him. He moved his feet much better than I expected.”“I wanted to take him out, but it felt like I was just spinning my wheels while I fought.”By winning his first title defense, the 25-year-old Berchelt improved his record to 32-1 with 28 wins by knockout, while Miura’s record fell to 31-4 with two draws.Miura held the title until he was beaten by Mexico’s Francisco Vargas on Nov. 21, 2015. Vargas lost his second title defense to Berchelt in January. IN FIVE EASY PIECES WITH TAKE 5 KEYWORDScenter_img Takashi Miura, WBC super featherweight, Miguel Bercelt INGLEWOOD, CALIFORNIA – Takashi Miura failed to reclaim his WBC super featherweight championship Saturday, losing a unanimous decision to Mexico’s Miguel Berchelt.Berchelt knocked the 33-year-old Miura down in the first round, and the former champ found himself playing catch-up. Miura, the top-ranked challenger, found his rhythm as the fight wore on but he was unable to overturn his early points deficit against the speedy Berchelt.last_img read more

Losing skid ends at 5 games for Mississippi State

first_imgSTARKVILLE – After losing five straight and shooting 24-percent of their 3-pointers on the year, Mississippi State was a team in need. The Bulldogs found their remedy Tuesday night, hitting 8 of 15 from 3-point range en route to a 70-47 victory over Jacksonville.“I think that we did a much better job of knowing when our shot was coming,” Bulldogs head coach Rick Ray said of the shooting success. “We talked about being down and ready to shoot and that made a big difference.”The Bulldogs (6-5) shot 57 percent from the field and outrebounded the Dolphins 35-18.Mississippi State never trailed and kept a double-digit advantage for the majority of the second half.Fred Thomas scored 16 points on 5-of-10 shooting, including two 3-pointers, and grabbed six rebounds. Travis Daniels scored 13, including hit 2 of 4 3-pointers, and had eight boards.“We wanted to come out this game aggressive on offense and coach wanted us to play with a little more confidence than we’ve been playing our last few games,” Thomas said of the offensive approach. “We just wanted to be aggressive on the offensive end.”Junior guard Andris Misters led the Dolphins (4-10) with 13 and Kori Babineaux scored 11, though the two combined to make just nine of their 28 shots.Jacksonville shot 37 percent from the field, including 28 percent in the second half.MSU never looked back after leading 9-0 with just under 16 minutes remaining in the first half. The Bulldogs shot 60 percent from the field in the first half, hitting 15 of 25 field goal attempts, and made 4 of 8 from beyond the arc to lead 36-27 at halftime. Thomas led all scorers with eight points and two 3-pointers and grabbed five rebounds.“The last part of the first half they scored on 10 of their 12 possessions,” Ray said. “We can’t go into the half like that. I thought in the second half we gave a great effort on the defensive end. Offensively, we made some shot because of the flow of our offense.”The Bulldogs tightened up on defense in the second half and jumped to a 44-30 lead after a 6-0 run with 12:51 remaining.Jacksonville cut the lead to nine with over 11 minutes to play, but the Bulldogs outscored the Dolphins 9-3 over the next two minutes to take their largest lead at 54-39 with 9:15 remaining. The lead would not drop below 10 points the rest of the way.MSU finished off the game out-scoring the Dolphins 16-8 and earned their first win in over a month of play. TIP INS Mississippi State: The Bulldogs hit 53 percent of their 3-pointers on Tuesday night. MSU has averaged 24 percent on the season from beyond the arc.Jacksonville: After scoring 27 points on 45.8 percent shooting in the first half, the Dolphins managed just 20 points and 28 percent shooting in the second half. They also grabbed just 10 rebounds in the second half. WHERE IS WARE? The win for the Bulldogs came without one of its best players in junior center Gavin Ware. The Starkville native is to be out of action for the next two weeks with an ankle injury. In his absence, freshmen Oliver Black and Fallou Ndoye logged 49 combined minutes with six points and seven rebounds between the two. DOUBLING UP In addition to a game-high 16 points from Fred Thomas, Daniels added a near-double-double with 13 points and eight rebounds. The juniors were two of three Bulldogs in double digits as Roquez Johnson managed 11 points and eight rebounds of his own. UP NEXT: Mississippi State plays McNeese State at home on Tuesday, December 30.Jacksonville visits Jacksonville State on Saturday, December 27.last_img read more

Ramsey wants QPR job – and defends SWP

first_imgSee also:Thrashing at City confirms QPR’s relegationMan City v QPR player ratings Chris Ramsey defended Shaun Wright-Phillips in the aftermath of a 6-0 defeat at Manchester City that confirmed QPR’s relegation. Wright-Phillips, returning to his former club, received rapturous applause from the City fans when he was brought on towards the end of the game – but was booed by the travelling Rangers fans.Asked if Wright-Phillips was one of the “bad eggs” recently referred to QPR midfielder Joey Barton, head coach Ramsey: “I wouldn’t say Shaun particularly, because Shaun’s been on the bench most of the time.AdChoices广告“I’ve used him when I’ve seen it was the right time to use him. There’s obviously other players who could’ve helped us, (but) Shaun has trained fantastically and he’s been on the bench.Wright-Phillips has been a flop since being signed from Man City“Players had tired legs and I thought it would have been an injustice to bring on a youngster who would’ve probably damaged his confidence more than it would have for a senior pro coming on the pitch.”Ramsey added: “I think Joey’s comment about the bad eggs, if you go to any club there’s going to be bad eggs.“What Joey probably alluded to was that there are people who could’ve helped us but haven’t helped us, and I don’t want to expand on that.”Ramsey reiterated his desire to continue at the helm despite the heavy defeat and just two wins since taking charge in early February.He said: “I know that generally people look for heads when there’s a heavy defeat.“I’m hoping they make a positive decision towards me and I’m at the helm to help them in their long-term plans.”Charlie Austin’s goals were not enough to keep QPR upRamsey blamed Rangers’ humiliating loss at the Etihad Stadium on their defensive mistakes – particularly in the build-up to City’s third goal.He said: “We talked about certain things before the game and one or two switched off and didn’t do it. Then all of a sudden you’ve got a mountain to climb“When you have individual mistakes that we have coming into the second half, that killed us really. Yhe third goal was just an individual mistake.“Then it’s very difficult when you’re out there in front of that crowd when they’re popping the ball about.“I don’t think they gave up, I just think that on the day our quality was nowhere near what it should be for a Premiership team.” Follow West London Sport on TwitterFind us on Facebooklast_img read more

Man in car chases former colleague in Green Bay’s Lambeau Field parking lot

first_imgRaymond Boyd/Getty Images(GREEN BAY, Wisc.) — A man rammed his car into five cars in the parking lot of Green Bay’s famed Lambeau Field before chasing an employee with his car and then crashing.The driver, whose name has not been released but was identified as a 20-year-old Green Bay resident, was arrested six minutes after the incident began on Friday afternoon.Just after 1 p.m., emergency dispatchers began receiving 911 calls from the ramp of Lambeau Field, which originally came in as active shooter calls, Green Bay Police Chief Andrew Smith said in a press conference Friday afternoon. Police officers responded to the scene within five minutes and apprehended the suspect just a minute after, he said.When authorities arrived, they learned that there was no active shooter.Smith said that both the suspect and the victim from the dispute on Friday were at one point employees of the food service contractor used at the stadium. The suspect was fired from his job earlier this month after an incident with the victim, according to officials.“Apparently, he was involved in a disturbance on Dec. 3 with a fellow employee, and that was a physical altercation, and he was ultimately fired from his employment at the food service agency,” Smith said.Smith said the suspect found the victim sitting in his car and then used his vehicle to hit the victim’s car. When the victim got out of his car, the suspect drove after him as the victim fled on foot.Shortly before police received calls about the incident, the suspect is believed to have gone to a police station to discuss his termination, officials said. About 20 minutes after making the report, the suspect then drove to the stadium and located the other employee with whom “he had the original dispute,” Smith said.The steel arm that is normally down when the loading dock isn’t in use was up because employees were loading trucks in and out at the time, which allowed the suspect to drive his vehicle down the ramp and up another ramp that led to storage rooms near Lambeau Field, where the suspect crashed his car inside.Smith said the investigation is ongoing, and “anybody that saw this guy chase this victim, we want to interview them.” The suspect will also be interviewed by detectives about the original dispute, Smith said.The vehicle is still inside the building and will remain there until hazmat and the bomb squad determine there is nothing dangerous inside, Smith said, adding that no weapon has been located.Photos from the scene show one vehicle on top of another car, and while Smith said “it’s going to be a while until that particular part of the parking lot is cleared,” he said it should have no interference with Saturday’s scheduled home game between the Green Bay Packers and the Minnesota Vikings.Local ABC affiliate WBAY-TV said that the first reports from the scene initially claimed there was an active shooter at Lambeau Field, but police have since said there were no guns involved.Copyright © 2017, ABC Radio. All rights reserved.Powered by WPeMatico Relatedlast_img read more

Rises recorded in most cattle classes

first_imgTHERE were good gains for vendors last week at Baw Baw Livestock Exchange, Warragul, as rises were recorded in all…[To read the rest of this story Subscribe or Login to the Gazette Access Pass] Thanks for reading the Pakenham Berwick Gazette. Subscribe or Login to read the rest of this content with the Gazette Digital Access Pass subscription.last_img