宁波 道行宫 880

Where Art and Fly Fishing Converge

first_img Email Stay Connected with the Daily Roundup. Sign up for our newsletter and get the best of the Beacon delivered every day to your inbox. When it comes to their craft, many artists are often driven to contribute to society, usually with a conversation-starting piece or with a direct, tangible impact to the community around them. For Whitefish painter Jane Latus Emmert, the chance to do both presented itself this year when she was asked to decorate a vintage trailer used by one of the members of the traveling group Sisters on the Fly. “It’s really fun to have a canvas that big,” Emmert said in an interview last week. On Sept. 14, the public will be able to see Emmert’s artwork as well as that of many other artists at a new community event called Fish the Fish, taking place from 11 a.m. to 4 p.m. at the base lodge at Whitefish Mountain Resort.Fish the Fish is a fundraiser for Casting for Recovery, which is a national nonprofit that provides opportunities for women who have been affected by breast cancer to connect with nature through fly fishing.Locally, Casting for Recovery puts on a fishing retreat in West Glacier for breast cancer survivors. Fish the Fish is organized by the Whitefish Knotty Nymphs, a group of women who are passionate about fly fishing and the Flathead community. The Sept. 14 event will include myriad fly-fishing activities, including a casting contest, as well as a cookout with hamburgers and hot dogs, and beer from the Ninkasi Brewing Company. Exhibitors at the event will include Simms, Sage, Scott, Lakestream Outfitters, Spotted Bear Ranch, Flathead Valley Trout Unlimited and more. There will also be a raffle, with the grand prize of a Spotted Bear Ranch fly-fishing trip valued at $2,300. Money raised from Fish the Fish will go toward sending local breast cancer survivors to West Glacier for a Casting for Recovery trip. The 60-plus trailers that will be on display are the homes of the members of Sisters on the Fly, which boasts a national membership of about 4,000 women who have bonded through fly fishing, fixing up their trailers and heading out on “exceptional adventures.”Emmert said a local woman contacted her and asked her to paint her fixed-up vintage trailer. The resulting design is based entirely on a Glacier National Park theme, Emmert noted, including a woman fly fishing, a sign post pointing out various trails, mountain goats, and the trailer’s name, DragOn Fly.The trailers all feature unique designs, and are more than just pieces of art.“This is how they travel,” Emmert said. “This is their little home.”Emmert said she was pleased to support the Sisters on the Fly because she is an avid angler herself, and works as a fly fishing instructor for Casting for Recovery. Working with the breast cancer survivors is a rewarding and humbling experience, she said. “A lot of these ladies, once they are done with chemo, they don’t want anything to do with a support group or a hospital,” Emmert said. But gathering for a weekend with relative strangers who have gone through similar experiences draws the group close, and working in nature has its healing effects as well. It’s fun, there’s fresh air, and the physical act of casting the fly rod helps with strengthening their bodies, she said. They also learn new skills that help drive home the message of the fresh possibilities in life, Emmert said. Like how she learned to paint and draw at age 30 and then became an artist, Emmert believes the desire to learn something new can lead to unexpected places.As for the Fish the Fish event, Emmert will be on hand to volunteer, and said she is excited to look at the other trailer designs and chat with the Sisters on the Fly. “You never know, I might just be inspired to join myself,” she said. For more information on Fish the Fish, visit www.fishthefish2013.com. For more information or to donate to Casting for Recovery, visit www.castingforrecovery.org. For information on Jane Latus Emmert, visit www.montanajaneart.com.last_img read more

Fellow’s focus is foggy, froggy forest

first_imgIn the dark of the Sri Lankan cloud forest, the researchers’ only guide was the headlamps they used to light up the night, illuminating the cold, gray mist that drifted through the trees.They looked carefully as they walked among the trunks, the beams from their headlamps casting left and right, up and down. They examined rocks and branches, leaf litter and shrubs, tree trunks, and leaves high in the canopy. By and by, they found one, then another — small tree frogs that froze in the light and went suddenly silent.The frogs are a bit of living scientific gold. With amphibians declining around the world in what experts fear is a mass extinction crisis, these recently discovered tree frogs are strangely abundant and incredibly varied, an overlooked yet amazing display of biological diversity in a part of the world where British and Sri Lankan naturalists had worked for a century.For the next two years, Sri Lankan biologist Madhava Meegaskumbura will be working at the Harvard University Center for the Environment to understand more about these frogs, studying how they evolved, why they go extinct, and how to prevent that fate for those that still exist.“Sri Lanka is on the front lines of the global biodiversity crisis,” said Alexander Agassiz Professor of Zoology and Museum of Comparative Zoology Director James Hanken, with whom Meegaskumbura is working. “It is among the hottest of global biodiversity hotspots, even though less than 5 percent of original forest cover remains. This is true for the island’s amphibians, and especially tree frogs, which have undergone a unique and explosive adaptive radiation numbering hundreds of species.”Meegaskumbura, a Ziff Environmental Fellow at the Center for the Environment, is planning a trip back to Sri Lanka in December to further his work in the field, which has already astonished amphibian experts around the world.In 2002, Meegaskumbura, together with other Sri Lankan scientists and researchers from Boston University, told the world what they found: as many as 100 new species of tree frogs in the high cloud forests and lowland rainforests of Sri Lanka. The new frog species, most belonging to the genus Philautus, were found in remnant forests in a part of the island nation that had been largely deforested by British colonial planters to make room for plantations of tea, rubber, and cinchona, a tree whose bark is used to make the malaria treatment quinine.“I was just completely blown away,” said Boston University associate professor of biology and herpetologist Christopher Schneider. “I was completely stunned by the finding. It was clear that there was this enormous radiation of frogs in Sri Lanka that nobody had recognized. … I don’t know when the last such discovery was made.”The work was initially done under the auspices of a Sri Lankan nonprofit organization called the Wildlife Heritage Trust. Meegaskumbura joined the effort in 1998 and, together with Sri Lankan colleagues, helped confirm the unprecedented diversity using DNA techniques, examining museum specimens, observing behavior of living specimens brought back to the lab, and logging hours and hours in Sri Lanka’s high remnant forests.“There’s obviously so much left to discover; that’s what’s exciting about Madhava’s discovery,” said Wildlife Heritage Trust founder Rohan Pethiyagoda.In 1998, Meegaskumbura contacted Schneider, who became his doctoral adviser and helped guide several more years of work on the frogs. Meegaskumbura completed his doctoral degree at Boston University in 2007.For two and a half years, Meegaskumbura, mainly together with colleague Kelum Manamendra-Arachchi, collected frogs and other relevant data in the forests. The work had to be done at night, when the frogs were active, and Meegaskumbura worked in the forests from 7 p.m. until 1 a.m. four or five nights a week, logging hundreds of hours.Researchers exhaustively detailed what they found, recording frog calls and noting where each was found, what type of surface it was on, elevation, humidity, temperature, and other variables that, as they accumulated, painted a picture of the different species’ habits.“The diversity of habitats you have to sample is amazing, places normally you wouldn’t expect frogs,” Meegaskumbura said.Researchers also took tissue samples for DNA analysis and, in some cases, took the whole frog, either to be preserved as part of a research collection or to observe breeding behavior in a captive setting.The forests were often difficult to traverse. The reason the forests survived is that they are perched on steep terrain unsuitable for farming. They held hidden dangers, some natural, some not. Leeches and snakes call the forests home and Meegaskumbura said he once had a notebook knocked out of his hand only to turn and see the open, white mouth of the pit viper draped in a nearby shrub. The snake had struck but hit only the book.Researchers also had to be alert for manmade dangers. Hunters sometimes set up guns triggered by trip wires to catch wild pigs and other game. A wrong step could blow away a knee or a hip, depending on the height of the hunters’ quarry, Meegaskumbura said.With the conflict between the government and Tamil separatists having ravaged Sri Lanka for the past 30 years, armed personnel could be another nighttime hazard. Meegaskumbura recalled one night when trucks full of men began shooting in the researchers’ direction from a road. He doesn’t know whether they were shooting live ammunition or not, whether they were hoping to hit something or just training, but he and his colleagues took cover behind the trees until the trucks passed, just to be sure.The research so far has done more than bring to light the new frog species, Meegaskumbura said. The DNA work on the frogs has informed science’s understanding of their relationships to each other, reducing the number of main genera of Sri Lankan tree frogs from four to two, even though it increases the number of species within those groups. By searching museums for specimens of Sri Lankan frogs collected since the late 1800s, they have identified 19 species that are no longer found on the island and presumed to be extinct.“These early reference collections that are now housed in reputed natural history museums worldwide were instrumental in highlighting the extinction of species in Sri Lanka,” Meegaskumbura said.Their studies have shown that most of the frogs are terrestrial direct developers, Meegaskumbura said. Instead of laying eggs in the water, most of the new species lay eggs on land, skipping over the aquatic tadpole phase and hatching as juvenile frogs right from the eggs. Meegaskumbura said he believes this trait may be a key to their amazing diversity. Being able to have young independent of water, these frogs were able to venture far from streams and ponds and exploit a whole host of environmental niches unavailable to frogs whose reproductive needs tie them to water.“It gives them ecological opportunity to diversify,” Meegaskumbura said.Though the frogs don’t need water to breed, they still need moisture. The misty forests provide a damp environment for these direct breeders to lay eggs in. While one type of direct breeder buries their eggs in the forest floor, protecting them from fluctuations in temperature and humidity, another type sticks their eggs to foliage and is very vulnerable to drops in humidity.That characteristic may make them sensitive to changes in the forest, Meegaksumbura said, either forest fragmentation that dries the interior out, or to a global warming that might raise temperatures and lower humidity.“Global warming could have a devastating effect on these frogs. These are mountain isolates restricted to small areas,” Meegaskumbura said. “They could go extinct quite quickly.”As part of his work at Harvard, Meegaskumbura wants to develop computer models that might help predict what kinds of changes the forests and frogs might face under different environmental circumstances, to help design conservation policies.“The Environmental Fellows program was created to support the professional development of outstanding young scholars tackling complex environmental problems,” said Harvard University Center for the Environment Managing Director James Clem. “Madhava’s extraordinary field research as a graduate student has laid the foundation for exciting new insights to come as an Environmental Fellow.”[email protected]last_img read more

Accidental Discovery of New T-Cell Hailed as Major Breakthrough for ‘Universal’ Cancer Therapy

first_imgCardiff researchers have now discovered T-cells equipped with a new type of T-cell receptor (TCR) which recognizes and kills most human cancer types, while ignoring healthy cells.RELATED: FDA Approves Pancreatic Cancer Drug Treatment After It Was Shown to Double Patient LifespansThis TCR recognizes a molecule present on the surface of a wide range of cancer cells as well as in many of the body’s normal cells but, remarkably, is able to distinguish between healthy cells and cancerous ones, killing only the latter.The researchers said this meant it offered “exciting opportunities for pan-cancer, pan-population” immunotherapies not previously thought possible.Photo by Cardiff UniversityHow does this new TCR work?Conventional T-cells scan the surface of other cells to find anomalies and eliminate cancerous cells—which express abnormal proteins—but ignore cells that contain only “normal” proteins.The scanning system recognizes small parts of cellular proteins that are bound to cell-surface molecules called human leukocyte antigen (HLA), allowing killer T-cells to see what’s occurring inside cells by scanning their surface.MORE: Scientist Who Helped Develop Breakthrough Ovarian Cancer Treatment Donates All $1.2 Million in ProfitsHLA varies widely between individuals, which has previously prevented scientists from creating a single T-cell-based treatment that targets most cancers in all people.But the Cardiff study, published this week in Nature Immunology, describes a unique TCR that can recognize many types of cancer via a single HLA-like molecule called MR1.Unlike HLA, MR1 does not vary in the human population—meaning it is a hugely attractive new target for immunotherapies.Andrew Sewell and Garry Dolton / Cardiff UniversityWhat did the researchers show?T-cells equipped with the new TCR were shown, in the lab, to kill lung, skin, blood, colon, breast, bone, prostate, ovarian, kidney and cervical cancer cells, while ignoring healthy cells.To test the therapeutic potential of these cells in vivo, the researchers injected T-cells able to recognize MR1 into mice bearing human cancer and with a human immune system.CHECK OUT: Husband-Wife Duo Has Developed ‘Gene and Cell Therapy’ Cancer Vaccine Now Being Tested on PatientsThis showed “encouraging” cancer-clearing results which the researchers said was comparable to the now NHS-approved CAR-T therapy in a similar animal model.The Cardiff group were further able to show that T-cells of melanoma patients modified to express this new TCR could destroy not only the patient’s own cancer cells, but also other patients’ cancer cells in the laboratory, regardless of the patient’s HLA type.Professor Andrew Sewell, lead author on the study and an expert in T-cells from Cardiff University’s School of Medicine, said it was “highly unusual” to find a TCR with such broad cancer specificity and this raised the prospect of “universal” cancer therapy.“We hope this new TCR may provide us with a different route to target and destroy a wide range of cancers in all individuals,” he said.RELATED: Apples, Tea, and Moderation—The 3 Ingredients for a Long Life“Current TCR-based therapies can only be used in a minority of patients with a minority of cancers.“Cancer-targeting via MR1-restricted T-cells is an exciting new frontier – it raises the prospect of a ‘one-size-fits-all’ cancer treatment; a single type of T-cell that could be capable of destroying many different types of cancers across the population.“Previously nobody believed this could be possible.”What happens next?Experiments are under way to determine the precise molecular mechanism by which the new TCR distinguishes between healthy cells and cancer.The researchers believe it may work by sensing changes in cellular metabolism which causes different metabolic intermediates to be presented at the cancer cell surface by MR1.MORE: Broccoli Isn’t Just Good For You—Scientists Find It Holds Molecule That Could Be the ‘Achilles’s Heel’ of CancerThe Cardiff group hope to trial this new approach in patients towards the end of this year following further safety testing.Professor Sewell said a vital aspect of this ongoing safety testing was to further ensure killer T-cells modified with the new TCR recognize cancer cells only.“There are plenty of hurdles to overcome however if this testing is successful, then I would hope this new treatment could be in use in patients in a few years’ time,” he said.Professor Oliver Ottmann, Cardiff University’s Head of Haematology, whose department delivers CAR-T therapy, said: “This new type of T-cell therapy has enormous potential to overcome current limitations of CAR-T, which has been struggling to identify suitable and safe targets for more than a few cancer types.”Professor Awen Gallimore, of the University’s division of infection and immunity and cancer immunology lead for the Wales Cancer Research Centre, said: “If this transformative new finding holds up, it will lay the foundation for a ‘universal’ T-cell medicine, mitigating against the tremendous costs associated with the identification, generation and manufacture of personalized T-cells.“This is truly exciting and potentially a great step forward for the accessibility of cancer immunotherapy.”Reprinted from Cardiff University(WATCH the explanatory video below)Be Sure And Share The Exciting News With Your Friends On Social Media…AddThis Sharing ButtonsShare to FacebookFacebookFacebookShare to TwitterTwitterTwitterShare to EmailEmailEmailShare to RedditRedditRedditShare to MoreAddThisMore AddThis Sharing ButtonsShare to FacebookFacebookFacebookShare to TwitterTwitterTwitterShare to EmailEmailEmailShare to RedditRedditRedditShare to MoreAddThisMoreResearchers at Cardiff University have discovered a new type of killer T-cell that offers hope of a “one-size-fits-all” cancer therapy.T-cell therapies for cancer—where immune cells are removed, modified and returned to the patient’s blood to seek and destroy cancer cells—are the latest paradigm in cancer treatments.The most widely-used therapy, known as CAR-T, is personalized to each patient, but it only targets a few types of cancers and has not been successful for solid tumors, which make up the vast majority of cancers.last_img read more

Seventh-Ranked Women’s Tennis Defeats Midwestern State, 6-3

first_imgThe UWF men went undefeated in doubles play, the No. 1 ranked tandem of Alex Peyrot and Pedro Dumont finished 8-5, No. 2 Gabriel Dias and Pedro Roese claimed an 8-5 win and Warren Kuhn and Pablo Tellez emerged with an 8-6 triumph. The seventh-ranked women advanced to 10-5 on the season with a 6-3 victory over the 15th-ranked Mustangs, while the ninth-ranked men remained perfect against NCAA competition after a 9-0 win against MSU’s 21st-ranked squad. It was also UWF’s eight shutout in 13 matches. The Argonauts won four singles matches with three of those coming in three sets. Both Heather Mixon and Samantha Echevarria dropped their first sets before regrouping for the victories. Mixon was down 4-0 in her second set before winning the final 12 games in the match. WOMEN’S BOX SCOREPENSACOLA, Fla. – The Nationally ranked women and men’s tennis teams both had a victory against Midwestern State on Friday at the Ralph “Skeeter” Carson Tennis Complex. Both squads will return to action on Saturday at home against Gulf South Conference opponent West Alabama at 2 p.m. center_img  Print Friendly Version In singles play, the Argos won the first five positions in straight sets. Sebastian Sanchez won his match at No. 6 via a third-set super-tiebreaker after losing his first set. On the women’s side, the Argos went ahead 2-1 in doubles. The No. 1 duo of Paula Lopez and Paula Coyos defeated the Mustangs 8-3 before Diana Vlad and Valeria Mantilla secured an 8-6 win at No. 3.last_img read more