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PEPFAR, launched as an emergency response to AIDS, has built a bridge to the future

first_img The Coptic Hospital in Nairobi, Kenya, receives funding from the President’s Emergency Plan for AIDS Relief, or PEPFAR. Brent Stirton/Getty Images In 2011, I presented preliminary results from HPTN 052, a clinical trial conducted among nearly 1,800 “sero-discordant” heterosexual couples — one partner was infected with HIV, the other was not. HPTN 052 showed that consistent treatment with antiretroviral medications brought a 96 percent reduction in the risk of HIV transmission to the partner without HIV. Final results from that trial, and from others that followed, definitively demonstrated that treatment that durably reduces the amount of HIV in an individual’s body to an undetectable level lowers to virtually zero the risk of transmitting it to someone else.advertisement Related: An AIDS-free world is possible, but do we have the will to achieve it? First OpinionPEPFAR, launched as an emergency response to AIDS, has built a bridge to the future [email protected] PEPFAR’s mission has slowly been validated, largely by doing the right thing — providing access to treatment for people who need it. That may seem obvious, but over the years since PEPFAR began, we’ve continued to learn the overwhelming benefits of following the best medical practices. Just 15 years ago, in a historic act of global humanitarian leadership, President George W. Bush proposed in his 2003 State of the Union address the creation of the President’s Emergency Plan for AIDS Relief (PEPFAR). Later that year, Congress passed the United States Leadership Against HIV/AIDS, Tuberculosis and Malaria Act of 2003, which launched PEPFAR as a comprehensive response to the global AIDS crisis. It would go on to save millions of lives (and counting).Initiated as an emergency response to the global AIDS crisis, PEPFAR’s renewal every five years since 2003 has tracked the evolution of an unprecedented, multifaceted attack on a single disease. Along the way, it has provided a model of sustainable, evidence-based action against other preventable illnesses and deaths.Spurred by climbing HIV incidence and deaths, fractured families, and decimated communities around the world, PEPFAR’s evolving mission was sparked by a simple vision: that even in the absence of a cure or a vaccine for HIV infection, accelerated access to services could reverse the trajectory of the epidemic in resource-limited countries.advertisement Tags advocacyCongressglobal healthinfectious diseasecenter_img By Myron S. Cohen Nov. 28, 2018 Reprints Why aren’t gay teens taking a daily PrEP pill to prevent HIV? In the meantime, results from the Strategic Timing of AntiRetroviral Treatment (START) study, which explored the possible benefits of starting antiretroviral treatment as soon as possible after infection with HIV, showed that this strategy reduced the risks of serious illness by more than half. START reinforced the impetus for ensuring that immediate treatment be accessible for all people diagnosed with HIV.During the 15 years of PEPFAR’s existence, discoveries of new medicines and new modes of delivery have simplified treatment and lowered the cost of supplying it. Today, people living with HIV can suppress the virus to undetectable levels with uninterrupted access to HIV treatment. Where available and affordable, that can mean taking just one pill a day.Those key findings — the importance of viral suppression and early access to medication — have informed PEPFAR’s goals, and the plan has set an example for later responses to disease. Today, PEPFAR-supported treatment has prevented mother-to-child transmission of HIV among more than 2 million babies who would otherwise have been infected. It has also made anti-HIV treatment accessible for more than 14 million men and women in PEPFAR-supported countries.Population-based surveys across 10 countries in Africa have shown that the number of people newly infected with HIV has fallen in direct proportion to the increased rollout of antiretroviral treatment. About the Author Reprints Related: As a treatment program, PEPFAR is a success. But it is much more than that. Following science, PEPFAR now provides proven HIV prevention interventions, including circumcision and the use of antiretroviral medicines for pre-exposure prophylaxis (PrEP).Through all of this, PEPFAR has maximized all possible efficiencies. It can no longer scale up treatment without cutting other key endeavors. The spread and toll of HIV remains a crisis and the need to confront it is urgent. After a decade of flat funding, 15 million people living with HIV worldwide today do not have access to treatment. That’s a problem on two levels. Early and reliable treatment protects individuals living with HIV and also prevents their transmitting the virus to others. It can also help prevent infection with tuberculosis, a curable disease that is the leading killer of people with HIV.The House of Representatives approved the PEPFAR reauthorization on Nov. 13. I hope the Senate will swiftly follow suit. Earlier this year, the Senate proposed a $50 million increase for PEPFAR, while the House proposed an additional $41 million for USAID’s TB program. For this year’s reauthorization, increasing funding for the program will be critical.We know what to do: Diagnosing and treating everyone with HIV leads to normal life spans and stops the spread of the virus. On its own, that won’t be enough to end the threat of HIV. The quests for a vaccine and a cure continue. But the course is clear, and staying the course is imperative, with PEPFAR as a bridge to a world in which HIV no longer presents a public health threat to any population in any country.Myron S. Cohen, M.D., is the architect and principal investigator of the multinational HPTN 052 trial and a professor of medicine, microbiology and immunology, and epidemiology at the University of North Carolina at Chapel Hill. He serves on advisory boards for Merck and Gilead related to the prevention of HIV infection. Myron S. Cohenlast_img read more

Dow tumbles on news U.S. tax cuts may be delayed

first_img Share this article and your comments with peers on social media Facebook LinkedIn Twitter S&P/TSX composite hits highest close since March on strength of financials sector Canada’s main stock index headed lower Thursday as American stocks dropped sharply on news that U.S. President Donald Trump’s tax cut plans may be delayed. The S&P/TSX composite index was down 23.26 points to 16,082.09 in a broad-based decline that saw most major sectors finish in the red. Related news David Hodges center_img TSX gets lift from financials, U.S. markets rise to highest since March Toronto stock market dips on weakness in the energy and financials sectors Keywords Marketwatch South of the border, cautious investors initiated a sell-off, with technology and industrial companies taking the biggest losses, after Senate Republicans surprised Wall Street by proposing a delay in cutting corporate taxes. Senate Republicans are rolling out their own tax bill, which would delay the corporate tax rate cut until 2019, instead of 2018 under the House bill. Both bills would lower that rate to 20% from 35%. Postponing the tax cut would reduce the costs of the bill, which is projected to add more than US$1 trillion to the U.S. debt. The Dow Jones industrial average was down 101.42 points to 23,461.94, after falling as much as 253 points earlier in the session. The S&P 500 index was down 9.76 points to 2,584.62 and the Nasdaq composite index was down 39.07 points to 6,750.05. “Wall Street’s slumping basically on a fear about Trump’s tax cut plan. That’s weighing on things,” said Jillian Bryan, vice-president at TD Wealth Private Investment Advice. “Really, he’s been ineffectual at getting any changes across at all so far if you look at health care and now these proposed tax changes.” In Canadian corporate news, mining company Cameco Corp. saw its shares increase 2.96% to $11.84 at the closing of markets Thursday. The movement follows its announcement Wednesday that it will temporarily suspend operations at its McArthur River mine and Key Lake milling operation by the end of January because of low uranium prices. Meanwhile, shares of Eldorado Gold Corp. moved up 3.87% to $1.61 after the miner said it is suspending work at its Skouries development project amid its ongoing dispute with the Greek government. On the energy front, pipeline giant TransCanada Corp.’s stock dipped 0.29% to $61.75 after it reported revenue fell to $3.24 billion compared with $3.63 billion in the same quarter last year. In commodities, the December crude contract added US36¢ to US$57.17 per barrel and the December natural gas contract was up US3¢ to US$3.20 per mmBTU. The December gold contract gained US$3.80 to US$1,287.50 an ounce and the December copper contract was down a penny at US$3.09 a pound. In currency markets, the Canadian dollar strengthened against a weakening greenback, trading at an average price of US78.79¢, up 0.23 of a U.S. cent. With files from The Associated Presslast_img read more

Suzuki’s bird of prey, the 2022 Hayabusa, has finally arrived

first_img ‹ Previous Next › PlayThe Rolls-Royce Boat Tail may be the most expensive new car everPlay3 common new car problems (and how to prevent them) | Maintenance Advice | Driving.caPlayFinal 5 Minivan Contenders | Driving.caPlay2021 Volvo XC90 Recharge | Ministry of Interior Affairs | Driving.caPlayThe 2022 Ford F-150 Lightning is a new take on Canada’s fave truck | Driving.caPlayBuying a used Toyota Tundra? Check these 5 things first | Used Truck Advice | Driving.caPlayCanada’s most efficient trucks in 2021 | Driving.caPlay3 ways to make night driving safer and more comfortable | Advice | Driving.caPlayDriving into the Future: Sustainability and Innovation in tomorrow’s cars | Driving.ca virtual panelPlayThese spy shots get us an early glimpse of some future models | Driving.ca advertisement The 2022 version’s 110 pound-feet of torque is also down a smidge, but Suzuki does promise there’s a wider powerband, though for the life of me, I never ever heard anyone complain about the big ‘Busa’s paucity of mid-range grunt. Suzuki still lists the top speed as 299 kilometres per hour, but as anyone who’s ever ridden a Hayabusa in anger knows, that has more to do with calming regulators’ nerves than actually limiting speed.The same familiarity applies to the basic chassis, which, though somewhat lightened, remains the familiar twin-spar aluminum jobbie of the original. Oh, the front brakes are a little larger, the rotors now measuring 320 millimetres in diameter — and the calipers some stylish and powerful Brembo Stylemas. But other than the details — the rear subframe is a little lighter — it’s all familiar territory. One minor detail that aging Suzuki fans of speed might appreciate, however, is that the handlebars are now some 12-mm closer to the rider; no more hunching over back-breaking clip-ons. Yeah!  Trending in Canada What is all-new is the electronics package, now the most comprehensive in Suzuki’s lineup. Dubbed the Suzuki Intelligent Ride System, it includes an Inertial Measurement Unit powering a 10-stage traction control system; a wheelie control system with a similar number of settings (one presumes for different stages of crazed mono-wheeling); six different power modes (three preset and three customizable); a two-stage up and down quick shifter; three-stage engine brake control; three-stage launch control; cornering ABS; cruise control; hill-hold control; and even slope descent control to prevent the rear wheel lifting under heavy braking when traveling down a hill.Phew! Perhaps most interesting is an active speed limit control — not a governor! — which lets the rider set a personalized top speed, lest the Hayabusa’s famous facility for exceeding speed limits not be in the spirit of stunting laws.One thing we’re glad Suzuki didn’t futz with is the big bird’s styling. Immediately familiar, there have been some aerodynamic changes — again, think of a Japanese falcon diving at 200 miles per hour — that include an even slipperier front fairing and rear tail unit. But, other than some pretty snazzy paint jobs and even larger twin exhausts, Hayabusa enthusiasts will not feel slighted. We encourage all readers to share their views on our articles using Facebook commenting Visit our FAQ page for more information. So, if you’ve got $22,399, drag racing’s favourite son has returned and will be in Suzuki dealerships across the country soon. See More Videos Road Tests First Ride: 2020 Suzuki V-Strom 1050XAby Costa Mouzouris | January 30, 2020 RELATED TAGSSuzukiMotorcycleFlexMotorcyclesMotorcyclesNew VehiclesFalconFlexSpeedSuzukiSuzuki Hayabusa Trending Videos It’s been a gestation period worthy of an elephant, a new version of Suzuki’s iconic Hayabusa rumoured, teased and, for fans of the world’s fastest motorcycle, anticipated for at least five years now.So many leaked patents, mock-ups, and spy shots have made the rounds of the motorcycling press that a cottage industry sprung up just to manage the latest sighting of the dive-bombing — Hayabusa is the Japanese name for a peregrine falcon, which can hit up to 325 kilometres an hour in a vertical hunting dive — GSX1300R.The biggest surprise is that the big Gixxer’s engine remains largely unchanged, the 1,340-cc inline-four sharing the previous model’s basic bore, stroke, and compression ratio stats, the rumours of a 1,440-cc version or even a supercharger variant proving as false as a trumped-up election. There’s still a whopping 187 horsepower available, even if that’s a little down on the previous generation’s 194 ponies, mainly — as we’ve all been warned — because the new bike needed to meet Europe’s new, more-stringent Euro5 emissions standards. First Look: 2022 Lexus NX The sport-cute’s looks have been softened, but its powertrains and infotainment offerings have been sharpened The Rolls-Royce Boat Tail may be the most expensive new car ever COMMENTSSHARE YOUR THOUGHTS RELATEDlast_img read more

CU-Boulder Proposes Fast Track Plan For New Student Housing

first_img Published: Jan. 16, 2001 The University of Colorado at Boulder is moving quickly on a “pre-development schedule” for Williams Village student housing development, according to Paul Tabolt, vice chancellor for administration, who oversees the campus master planning process. Tabolt said a financial analysis and implementation plan are being prepared in conjunction with a market analysis to determine if a third-party developer could hasten the project to a fall 2003 completion date. “Student housing has been a controversial issue in Boulder,” Tabolt said. “We suspended planning for additional student housing in l996 following a negative reaction by the city to additional housing at Williams Village. The city now agrees with the campus that there is a need for more student housing. We are eager to move the project forward as rapidly as possible.” The Colorado Commission on Higher Education will vote in February on CU’s master plan. If it is approved, the campus will then take a formal program plan and master site development plan for Williams Village to the University of Colorado Board of Regents and CCHE. After the Board of Regents and CCHE approve the program plan, the campus will be in a position to seek requests for proposals from third-party developers. “Using a third-party developer will enable us to complete the new residence halls on a faster timeline,” Tabolt said. “We haven’t done this before, but I’m hopeful that this will be an idea whose time has come.” It is expected that a private developer would build the housing units on university property, pay a lease fee for the site and retain ownership of the structures and operating authority during the term of the lease. Details of the proposal will be presented to the Board of Regents Strategic Planning Committee on Jan. 17.Fact SheetMeeting Future Student Housing NeedsUniversity of Colorado at BoulderContact: Paul Tabolt, (303) 492-7523Jan. 17, 2001The University of Colorado at Boulder follows a campus Master Plan to address future enrollment, research growth and academic initiatives. The new Master Plan was approved in l999 by the CU Board of Regents.FACTS- The University of Colorado at Boulder currently has 26,035 students. – The student body is expected to grow by .70 percent, or less than 1 percent, per year until 2008. – During this time, high school graduation rates are expected to increase by 10 percent to 15 percent. – The campus intends to continue housing freshmen on campus. There are 5,900 single beds available and 850 family housing apartments. This is adequate to serve all of the current freshman class but demand for campus housing among the entire student body exceeds the supply.- CU-Boulder currently houses 27 percent of the student population and plans to maintain or improve that percentage in the future.- The new campus Master Plan includes plans for new housing. The short-term plan adds about 500 new beds in a “village-style” environment organized around a common green and meeting/recreation spaces. The site has the capacity to eventually accommodate twice that number of beds, should city and campus needs dictate. Planners and architects plan to scale new buildings to minimize the impact on the residential neighborhood east of Bear Creek. – No student housing is proposed east of Bear Creek, an area that was designated for faculty and staff housing in the l990 master plan. – Funds to build additional housing are not appropriated by the taxpayers, though the state does grant the authority to use university-generated funds to build new residence halls. – The university cannot ask the state for authority to build new housing until it has an approved Master Plan. The university’s new Master Plan has been delayed due to controversies over historic preservation at Grandview Terrace.- The university hopes to move forward to develop additional housing as soon as it has an approved Master Plan. Share Share via TwitterShare via FacebookShare via LinkedInShare via E-maillast_img read more

Afternoon Brief, October 2

first_imgAdvertisement Facebook Share Linkedin ReddIt Trending Story:Sonoma County Harvest Fair Wine Sweepstakes AnnouncedA pinot noir, a chardonnay and a sparkling wine won the coveted sweepstakes awards Sunday night at the Sonoma County Harvest Awards Gala, with two of the three from the Russian River Valley appellation…Today’s News:Opus One Winery Ordered to Pay for Napa River ContaminationOpus One Winery has been ordered to pay more than $10,000 in monetary relief for contaminating the Napa River with grape waste last year…Drizly Brings Largest Online Alcohol Marketplace to Buffalo and AlbanyDrizly, the technology company behind the first and largest e-commerce alcohol app, brings a revolutionary way to shop for adult beverages to Buffalo and Albany, starting today…Napa Valley Vintners Statement on Watershed and Oak Woodland InitiativeIn early September, the Napa Valley Vintners announced that its Board of Directors was working with the local Watershed Protection Committee in support of the compromise Napa County Watershed and Oak Woodland Protection Initiative of 2018…Online Grape Pricing UpdateU.S. Renews World Trade Organization Complaint over Canadian Wine RetailingNew On-Product California Certified Sustainable Logo AvailableNapa Farm Bureau Will Oppose Oak Woodlands InitiativesPaso Robles Wineries Adjust for Challenges: Heat, Humidity and LaborCanThe Sideways Curse Has Lifted: Merlot Is Having a ComebackB.C. Winemakers Optimistic Smoke Taint Not an Issue After WildfiresNew Push to Replace Broken H-2A Farm Labor ProgramConstellation Brands’ Sales Growth in Fiscal 2Q18: Strong or Not?Winestyr Offers a New Twist on Wine Distribution in the United StatesParker Please Don’t GoBlogs:Customer Service CheckupHow Science Enhances the Art of WinemakingBest Practices for Gas Management at BottlingGet Your Email Delivered, Opened and Read with These 5 TipsWine Divide: Ordinary People and Enophiles Are Experiencing Different ProductsWineIndustry.Jobs:Sales RepresentativeMonvera Glass Décor – Napa, CA, United StatesBottling Sales SpecialistConfidential – Santa Rosa, CA, United StatesWine Equipment Sales RepresentativeConfidential – Santa Rosa, CA, United StatesMore Wine Industry Jobs…Feature Your Job Listing in the Afternoon BriefPeople:John Anthony Family of Wines Appoints Liza Butler, Vice President Product and CreativeMelissa Devore Joins Amici Cellars as Executive Vice PresidentYountville Parade Honors Mexican-Born Vineyard Workers for Decades of ServiceWine Expert Archie McLaren Focus of SLO History Center ExhibitWashington Wine’s Next Generation: David Rosenthal Makes Chateau Ste. Michelle’s Super Popular White WinesSupplier News:Vinventions Unveils New Logos and the Consolidation of Legal Entity NamesNew Method for Sulfite DeterminationCustomer Success Stories: Brown-Forman’s Chambord Holiday PackagingVinotemp Announces Plans to Manufacture at 100,000 Square-Foot Los Angeles-Based FacilityMore Supplier News …Vineyard & Winery:Hope Estate Winery Unveils New LookChâteau Lassègue Announces Partnership with Top Bordeaux Négociants for International DistributionItalian Winery Sues Peju Province Winery over “Liana”Settlement Ends Dispute over Proposed Flynnville Winery Near CalistogaHistoric Blessing of the Grapes at Robert Mondavi Winery Subscribe to the Afternoon Brief Home Afternoon Brief Afternoon Brief, October 2Afternoon BriefAfternoon Brief, October 2By Editor – October 2, 2017 27 0 center_img Pinterest Email Subscribe to the Afternoon BriefAdvertisement TAGSAmici CellarsArchie McLarenCanadaConstellation BrandsMelissa DevoreNapaOpus OnePaso RoblesRobert Mondavi WineryRobert ParkerSidewaysSLOSonoma County Harvest FairWashingtonYountville Twitter Previous articleNew On-Product California Certified Sustainable Logo AvailableNext articleRioja DOCa Announces Trade Industry Holiday Contest in the United States Editorlast_img read more

City Hall retreats from electric vehicle charging stations at the beach

first_imgHomeNewsCity CouncilCity Hall retreats from electric vehicle charging stations at the beach Aug. 02, 2017 at 6:40 amCity CouncilNewsCity Hall retreats from electric vehicle charging stations at the beachMatthew Hall4 years agoCity Halldaily presselectric carElectric Vehicle Action Planelectric vehicle charging stationsEV chargesplanning commissionSanta Monicasanta monica daily pressA car powers up at a bank of electric vehicle charging stations located at Virginia Avenue Park. (Daniel Archuleta [email protected])  The city’s electrical vehicle community supports expanding charging stations citywide but at the July 25 Council meeting, drivers rallied in opposition to the proposed construction of several charging stations in the city’s beach adjacent lots.At issue last week was a proposal pilot program with Southern California Edison to install chargers in the Civic Center parking lot and in the beach lots.Local drivers praised the City’s ongoing efforts to support electric vehicles but as a group, said the City hasn’t done enough to provide public chargers for residents and that resources should be focused on facilitating charging for residents of multifamily housing.City Manager Rick Cole acknowledged the city doesn’t have adequate charging facilities in the community and he said the city is working on expanding locations citywide. He said the beach proposal was a result of requirements imposed by the agreement with Edison.Under the terms of the pilot program, the utility company pays for infrastructure improvements necessary to install electrical vehicle chargers. However, the rules of the program require a minimum of 10 spaces and prohibit those ten from removing more than 4 percent from the total lot.In Santa Monica, that limited the options to the Civic Center, Beach lots and the city’s downtown garages. The Downtown lots can’t accommodate other requirements of the program such as construction of new disabled charging stations and the city was left with the Civic Center and the Beach.“This means Edison will only extend this to very, very large lots. So, it’s great for Dodger stadium, it’s great for the beach, it’s great for a college or a high school,” he said. “It’s not particular good for the kind of thing we want to do which is get chargers out into our neighborhoods and or into our local parks,” he said.However, given the community opposition to the plan, Cole said staff would drop plans to install chargers at the beach lot and instead ask Edison to revise the program.“It would be our recommendation, a revised recommendation to you tonight, to proceed forward to applying to Edison for the grant for the civic center parking structure, to give us authority to apply for additional chargers if Edison is willing to flex, which we don’t think they will, but if they were willing to flex to achieve chargers that would more directly benefit residents throughout our community,” he said. “That would be our revised recommendation to drop the beach lot based on the fact that it’s a fairly expensive for relatively small returns at this stage to our community.”New EV driver Paul Rosenstein said he had to adapt when he purchased an electric car.“I suddenly have to learn all about the charging issue which is no insignificant issue when you have an electric vehicle,” he said.He said the beach lot is fraught with problems for locals including a fee to enter the lot, a lack of overnight access and distance from homes.Resident William Claiborn said it was great that the city was working on EV chargers but said given the majority of residents live in multi-unit housing, the city should find a way to faciliatate charging for those residents.“The placement of these things is best in places where people who are residents can get to them and parking lots, paid parking lots, are not really those places, they are basically tourist places,” he said.City Hall is also working on an Electric Vehicle Action Plan.The document will provide a review of existing policies, plans and programs to support charging infrastructure on a state and regional level. Discuss recommended policy priorities to address current problems with EV Charging and EV utilization. Provide an implementation plan for all policy priorities that will require collaboration between various City departments and divisions, Southern California Edison, the City’s selected EVSE service provider, and community stakeholders and include appendices with resources including maps on current and proposed EV charging infrastructure and detailed material on multi-family unit dwelling (MUD) installation case studies and best practices.Planning Commission saw a first draft of the plan in July and the document will make the rounds at various boards and commissions with the goal of a final draft appearing before the council in [email protected] :City Halldaily presselectric carElectric Vehicle Action Planelectric vehicle charging stationsEV chargesplanning commissionSanta Monicasanta monica daily pressshare on Facebookshare on Twitteradd a commentDon’t Fandango, MoochElaine Polachek hired by Santa Monica collegeYou Might Also LikeFeaturedNewsBobadilla rejects Santa Monica City Manager positionMatthew Hall11 hours agoNewsWedding boom is on in the US as vendors scramble to keep upAssociated Press22 hours agoNewsCouncil picks new City ManagerBrennon Dixson22 hours agoFeaturedNewsProtesting parents and Snapchat remain in disagreement over child protection policiesClara Harter22 hours agoFeaturedNewsDowntown grocery to become mixed use developmenteditor22 hours agoNewsBruised but unbowed, meme stock investors are back for moreAssociated Press22 hours agolast_img read more

Genetics Leaves Central Dogma and Junk DNA in the Rear-View Mirror

first_img Email Print Google+ Linkedin Twitter Share Intelligent Design Genetics Leaves Central Dogma and Junk DNA in the Rear-View MirrorEvolution News @DiscoveryCSCMay 4, 2018, 1:48 AM Evolution Today, we look at some discoveries that continue to leave the Central Dogma and “junk DNA” in the rear-view mirror. Through the front windshield, we see discoveries about epigenetics coming fast.New Form of Regulatory DNAA “mysterious” form of DNA shaped like a four-stranded knot, once thought to exist only in the lab, has been discovered to be active in cell nuclei. Yasemin Saplakoglu reports in Live Science that “many scientists thought that it couldn’t possibly exist in human cells,” because it loves acidic environment not found naturally in the body. Called an i-motif, the structure has been now reported by Australian scientists in a paper in Nature Chemistry, and the rush is on to see what it does. Saplakoglu thinks “it may play an important role in regulating our genes.” Co-author Marcel Dinger sees much more to discover in the forward view:“There’s so much of the genome that we don’t understand, probably like 99 percent of it,” Dinger said. Seeing DNA folded like this in living cells “makes it possible to decode those parts of the genome and understand what they do.” [Emphasis added.]Bye-Bye Junk; Hello CaptainHow often have we heard about new roles for junk DNA? Here’s another: “A conserved function for pericentromeric satellite DNA” announced in the journal eLife by researchers at the University of Michigan. This one got promoted from junk to captain:A universal and unquestioned characteristic of eukaryotic cells is that the genome is divided into multiple chromosomes and encapsulated in a single nucleus. However, the underlying mechanism to ensure such a configuration is unknown. Here we provide evidence that pericentromeric satellite DNA, which is often regarded as junk, is a critical constituent of the chromosome, allowing the packaging of all chromosomes into a single nucleus.Old-school geneticists considered this kind of DNA as “junk” or “selfish” DNA that perpetuated itself for no purpose, says Science Daily. But lead author Yukiko Yamashita and colleagues “were not quite convinced by the idea that this is just genomic junk.” For one thing, it is highly conserved, so “If we don’t actively need it, and if not having it would give us an advantage, then evolution probably would have gotten rid of it. But that hasn’t happened.” When they took a closer look, they found that cells in fruit flies, mice, humans and probably all vertebrates cannot survive without it. Using a protein named D1 that binds to the satellite DNA, they found it provides vital attachment points for molecular machines that keep chromosomes in the nucleus. Without it, DNA would float off into buds with only part of the genome, and the cell would die.The similar findings from both fruit fly and mouse cells lead Yamashita and her colleagues to believe that satellite DNA is essential for cellular survival, not just in model organisms, but across species that embed DNA into the nucleus — including humans.Genetics Without the “Epi” Prefix Is IncompleteA geneticist at Johns Hopkins is telling colleagues not to forget the “epi” in genetics research. “In a review article published April 5 in the New England Journal of Medicine, scientist Andrew Feinberg, M.D., calls for more integration between two fields of DNA-based research: genetics and epigenetics.” It is essential for human disease prevention and mitigation, Feinberg notes, but from his vantage point, “scientists know comparatively little about how existing drugs may be altering patients’ epigenomes.” He suggests that combining genomewide and epigenomewide association studies can overcome problems of assigning cause and effect to specific alterations among either type of study alone.Identity Crisis SolvedWhy do cells with identical genes perform unique jobs? Consider how different a blood cell is from a brain cell, and yet they both share the same genome in their nuclei. Researchers at Trinity College Dublin explored the question of “cellular identity,” which they say is “central to the field of epigenetics,” and “made a significant discovery that explains how and why the billions of different cells in our bodies look and act so differently despite containing identical genes.”Central to this is a group of epigenetic regulators, called Polycombs, which are vital to regulating cellular identity in multicellular organisms of both the plant and animal kingdoms. The Bracken lab studies the biology of these Polycomb epigenetic regulators, and their newly discovered PALI1 and PALI2 proteins form a new family of Polycombs that are unique in that they are only present in vertebrates — they are not found in invertebrate animals, or plants.The uniqueness of these regulators to vertebrate animals does not mean that plants and invertebrates lack mechanisms to achieve cellular identity; they just have different ones.The Anti-DogmatistsConfidence in the Central Dogma been collapsing for a long time now. The idea that DNA is the master molecule, making RNA that makes proteins and that’s all you need to know — taught uncritically since the 1960s — cannot stand up to all the new discoveries. At The Conversation, Staffan Müller-Wille and Hans-Jörg Rheinberger explain “Why genes don’t hold all the answers for biologists.”It is still widely believed that the gene is the foundation of life — that its discovery has provided information about how all living beings are controlled by the genetic factors they inherit from their parents.But scientists and philosophers are beginning to doubt the relevance of the gene for understanding biology.Despite being central to the subject for over a century, there has never been a universally accepted, constant definition of what genes actually are. From the beginning, scientists have tried to link human characteristics to genes, but had limited success in establishing stable connections.Rheinberger is a historian of science at the Max Planck Institute. Together, the two produced a book called The Gene: From Genetics to Postgenomics that undermines the neat picture of genetics as a triumph of 20th-century science. While readers of the press release will enjoy the short video biography of Gregor Mendel, the 19th-century father of genetics whose work was largely ignored until well into the 20th century, genetics today is much more complicated. Biologists will of course continue to talk about genes in the future. But genes will no longer be seen as the blueprint for life, even if technological and medical applications of gene technology suggest this. Instead, they are increasingly seen as only one of the many resources that organisms make use of in adapting to challenges in their environments.ConclusionThe old genetics of the late 20th century was powerful enough evidence of intelligent design, with its systems of highly-accurate transcription and translation of encoded information. Now, we find that the old picture was far too simplistic. And the surprising lack of “genes” found by the Human Genome Project, feeding rumors of useless “junk” pervading our genome, is rapidly being supplanted by evidence of hierarchical codes and functions everywhere. If the old genetics was sufficient to allow A.E. Wilder-Smith to help convince Matti Leisola to become a Darwin Heretic in the 1970s (pp. 40-41), how much more will the flood of new discoveries, illustrated by these few examples, persuade the next generation of geneticists that Darwinism is hopelessly inadequate to account for the complexity of life? It’s like having to account for half a dozen codes instead of one. The future looks bright for ID in next-generation genetics, embedded in epigenetics. The nucleus is a whole new ball game.Photo credit: Jack, via Flickr. Recommended Origin of Life: Brian Miller Distills a Debate Between Dave Farina and James Tour Congratulations to Science Magazine for an Honest Portrayal of Darwin’s Descent of Man Requesting a (Partial) Retraction from Darrel Falk and BioLogoscenter_img Jane Goodall Meets the God Hypothesis Evolution NewsEvolution News & Science Today (EN) provides original reporting and analysis about evolution, neuroscience, bioethics, intelligent design and other science-related issues, including breaking news about scientific research. It also covers the impact of science on culture and conflicts over free speech and academic freedom in science. Finally, it fact-checks and critiques media coverage of scientific issues. Share “A Summary of the Evidence for Intelligent Design”: The Study Guide TagsA.E. Wilder-SmithAndrew Feinbergcentral dogmaDNAepigenetic regulatorsepigeneticsepigenomegeneticsHans-Jörg RheinbergerHeretic: One Scientist’s Journey from Darwin to DesignJunk DNAMarcel DingerMatti LeisolaMax Planck InstituteNew England Journal of MedicinePolycombsStaffan Müller-WilleThe Gene: From Genetics to PostgenomicsTrinity College DublinUniversity of MichiganYasemin SaplakogluYukiko Yamashita,Trending Email Print Google+ Linkedin Twitter Share A Physician Describes How Behe Changed His MindLife’s Origin — A “Mystery” Made AccessibleCodes Are Not Products of PhysicsIxnay on the Ambriancay PlosionexhayDesign Triangulation: My Thanksgiving Gift to Alllast_img read more

Fire service deal with number of gorse fires

first_img Fire service deal with number of gorse fires WhatsApp Arranmore progress and potential flagged as population grows Facebook Twitter Pinterest Twitter DL Debate – 24/05/21 Google+ Facebook RELATED ARTICLESMORE FROM AUTHOR WhatsAppcenter_img Important message for people attending LUH’s INR clinic The public are being warned to be vigilant after the fire service dealt with a number of significant gorse fires near Glenveagh National Park at the weekend.Four separate fires were brought under control by fire-fighters on Saturday afternoon, all in close proximately of each other.It’s not yet known what caused the fires although there are fears locally that two of them could have been started deliberately. Loganair’s new Derry – Liverpool air service takes off from CODA Pinterest Google+ Homepage BannerNews Previous articleNational Rally Championship organisers looking for replacement eventNext articleRussell Knox – Words can’t describe what winning the DDF Irish Open means News Highland By News Highland – July 9, 2018 News, Sport and Obituaries on Monday May 24th Nine til Noon Show – Listen back to Monday’s Programmelast_img read more

Men convicted of Letterkenny assault seek sentence review

first_img Twitter Twitter Pinterest Hospitalisations rise as Donnelly suggests masks will stay ’til autumn Facebook Two men jailed for an attack in Letterkenny which left Derryman Mark Mc Shane permanently brain damaged are appealing their sentences in Dublin today.Today’s Derry News is reporting that Alan Lackey and Aidan Mc Hugh, both of whom have served one year of the two year sentences they received will appeal their sentences today.Members of Mr Mc Shane’s family are travelling to Dublin this morning to address the panel of judges who will consider the appeal. They believe the original sentences were too lenient. Pinterest Disruption to cancer service will increase mortality – Oncologist RELATED ARTICLESMORE FROM AUTHOR WhatsApp Google+ Previous articleKilmacrennan crash victim namedNext articleHydrogen Highway to be created between Derry, Belfast and Dublin News Highland center_img Today is the 30th anniversary of Eddie Fullerton’s murder Google+ Men convicted of Letterkenny assault seek sentence review Donegal hoteliers enjoy morale boost as bookings increase By News Highland – February 22, 2010 Facebook 45 new social homes to be built in Dungloe Gardai investigate Castlefinn burglary News WhatsApplast_img read more

Marketing Internship at The Walt Disney

first_img Deadline: 15 December 2017Open to: open to all undergraduate students who have legal right to work in the UKBenefits: annual salary of 18,000 GBPDescriptionAre you an undergraduate looking for a challenging and rewarding 12-month internship with Disney?Imagine yourself in a paid Disney Professional Internship. Imagine working side-by-side with industry leaders in your field of study. Imagine gaining valuable skills to add to your degree within a family of legendary brands passionate about creating world-class experiences on a global scale. Disney offers a number of placements within their Marketing teams and their interns are fully integrated into the everyday tasks of one of their businesses e.g. Disney Channel, Walt Disney Studios, Disney Interactive, Disney Media Distribution or our Corporate group, playing a key role in providing commercial and creative support across the UK or EMEA.Disney will give you the opportunity to gain experience working for the world’s leading entertainment company. There is no better place to show what you’re made of – apply now!Location: United KingdomEligibilityMUST be an undergraduate returning to full-time education;MUST have the legal right to work in the UK;Applicants should be studying a relevant Marketing degree subject and be able to demonstrate a passion for forging a career in marketing;Strong MS Office skills essential;Great attention to detail and specifically the ability to work accurately under pressure;Good at prioritizing and natural ability to tackle various admin duties.BenefitsThe opportunity to develop your skills and experience with Disney and help build the foundations of your future career;The chance to work in a fantastic team environment, learning from the best and with the support of a brilliant community of interns;The opportunity to be part of Company-wide learning and development initiatives including training and networking sessions, participation in our Annual Learning Expo and more…The chance to attend Family and Friends movie screenings, seeing the latest Disney releases in our in-house cinema or in the West End;Ability to join charity projects within the community, participating in our Disney VoluntEar schemes;The annual salary of GBP 18,000 with 25 days holiday (plus bank holidays) and fabulous discounts on Disney products and shows.How to apply?Please apply with your CV and cover letter; please note applications without cover letters will not be considered.Your cover letter should include the following information and be around 400 words:Why have you chosen Disney?Why have you chosen this specific internship?Why should Disney choose you for the 12-month placement?In order to apply follow this link.For more information please visit the official website. ← Intrapreneurship MBA Scholarship at Imperial College Business School LinkedIn 0 Share 0 +1 Reddit Similar Stories Marketing Internship at The Walt Disneycenter_img Paid Internship at The Walt Disney in UK Leave a Reply Cancel ReplyYou must be logged in to post a comment. Tweet October 17, 2017 Published by rosica Pocket McGraw Fellowship for Business Journalism in USA →last_img read more